Like many of the early 80s groundbreaking "alternative" comedians she began her career as comedienne/actress/writer at "The Comedy Store" in London, where she met fellow comedians Adrian Edmondson (later her husband), Rik Mayall, Nigel Planer, Alexei Sayle and 'Peter Richardson' , who later opened his own club, "The Comic Strip", where these comedians quickly formed a regular format.

The Comic Strip team were transferred to television screens with great success as they al starred alongside each other in "The Comic Strip presents..." (1982) . After The Comic Strip she starred in a few episodes of "The Young ones" (1982), _"Girls on top" (1985)_ and "Happy Families" (1985).

 (Ab Fab) Saunders had created one of the most loved, funny, and creative TV Shows in BBC history. Three series were made, in 1995 the show was put on hold until Saunders began writing again and came back with a fourth series in 2001. She is always ready for charity as well, she has been doing "Comic Relief" with a lot of her comedy companions ever since 1986. The fifth series of Absolutely Fabulous came out in 2003, and a xmas special christmas 2004!!!